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Peptide record

TPDB63974

L5a Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB63974
L5a
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RRWQW
Physicochemical Analysis
C39H54N14O7
ANDCEGHILKMFPSTYV
RW
830.95
12.40
2
0
2
+2
-1.50
-2.860
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1323.79
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
5
C39H54N14O7
830.95
12.40
+2
-1.50
-2.860
Free
L
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
pEGFP-N1 plasmid and FITC dye
L5a-FITC were internalized at low concentrations (< 1μM)
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCC