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Peptide record

TPDB63972

SAP10 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63972
SAP10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
RRWKFFPWRR-NH2
Physicochemical Analysis
C75H107N25O11
ANDCEQGHILMSTYV
R
1534.84
12.88
5
0
4
+5
-1.28
-1.970
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
716.69
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
2
F
1
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C75H107N25O11
1534.84
12.88
+5
-1.28
-1.970
Amidation
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 , Hek-293T And Nih/3T3 Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
plasmid DNA
The highest transfection efficiencies of DNA/SAP10/PEI in different cells were always at N/P 20.
In vitro
CCCSSCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCC