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Peptide record

TPDB63964

CPP2 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63964
CPP2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRYARPYYRRR
Physicochemical Analysis
C83H137N37O17
NDCEQGHILKMFSTWV
R
1925.24
12.40
8
0
4
+8
3.94
-3.054
7.69
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
4470
232.18
3
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 3 V: 0
Chemical Descriptors
13
C83H137N37O17
1925.24
12.40
+8
3.94
-3.054
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Df-1, Vero And RAW264.7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC dye, SYTO 64 fluorescent dye, plasmids ,SUMO-Rep or SUMO-Cap protein and CAV VP3 gene
Cytoplasm and Nuclear Areas
61.37±2.07 internalization percentages of the cells treated with 5 μM CPP2
Clathrin- and Caveolae-dependent endocytosis and macropinocytosis
In vitro
CCHHHHTTCC
Additional Detail Fields 1 fields
CCHHHHTTCC