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Peptide record

TPDB63961

P9 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63961
P9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC labeled
Sequence
RRRRRWWPP
Physicochemical Analysis
C62H96N26O10
ANDCEQGHILKMFSTYV
R
1365.61
13.00
5
0
2
+5
1.25
-3.056
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
805.50
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
9
C62H96N26O10
1365.61
13.00
+5
1.25
-3.056
Free
FITC labeled
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Assay & Model

4−6 week old female BALB/c mouse weighing 18−22 g
4−6 week old female BALB/c mouse weighing 18−22 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Paclitaxel (PTX)
Cytoplasm
After 30 min of incubation, the intracellular concentration of PTX in the P9-PTX group (0.36 ± 0.12 mg/mL) was nearly 9-fold more than that of the free PTX group (0.04 ± 0.02 mg/mL), even nearly 3-fold more than that of the R7-PTX group (0.136 mg/mL)
In vitro and in vivo
CCCSTTGGGGGTSCC
Additional Detail Fields 1 fields
CCCSTTGGGGGTSCC