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Peptide record

TPDB63961

P9 Cell-penetrating Peptides modified_plain modified
9 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB63961
P9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 9-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC labeled
Sequence
RRRRRWWPP
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
9 main sequence record
Free Activity
FITC labeled Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Assay & Model

4−6 week old female BALB/c mouse weighing 18−22 g
4−6 week old female BALB/c mouse weighing 18−22 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Paclitaxel (PTX)
Cytoplasm
After 30 min of incubation, the intracellular concentration of PTX in the P9-PTX group (0.36 ± 0.12 mg/mL) was nearly 9-fold more than that of the free PTX group (0.04 ± 0.02 mg/mL), even nearly 3-fold more than that of the R7-PTX group (0.136 mg/mL)
In vitro and in vivo
CCCSTTGGGGGTSCC
Additional Detail Fields 1 fields
CCCSTTGGGGGTSCC