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Peptide record

TPDB63956

R11-PKI Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB63956
R11-PKI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
RRRRRRRRRRRTYADFIASGRTGRRNAI
Physicochemical Analysis
C146H261N71O36
CEQHLKMPWV
R
3587.13
12.96
14
1
7
+13
10.22
-2.039
38.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
41.54
5
Residue Composition
number
3
A
14
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
2
I
0
L
0
K
0
M
1
F
0
P
1
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 14 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
28
C146H261N71O36
3587.13
12.96
+13
10.22
-2.039
Free
L
Linear
Conjugation with rhodamine B
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO K1, HeLa, A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Fluorophore (rhodamine)
Greater than pAntp-PKI, Tat-PKI but equal to trans
In vitro
CCCTHHHHTTCTHHHHTTSCCCGGGGCC
Additional Detail Fields 1 fields
CCCTHHHHTTCTHHHHTTSCCCGGGGCC