Back to search

Peptide record

TPDB63953

P2 Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63953
P2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Hyaluronic acid (HA) modified quaternary nanocomplexes (Q-complexes).
Sequence
RRRRRRRRRRRRRRRRKMPNWTYRFRMTPRK
Physicochemical Analysis
C187H334N92O36S2
ADCEQGHILSV
R
4511.42
13.33
21
0
5
+21
14.59
-3.129
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
154.94
4
Residue Composition
number
0
A
19
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
2
M
1
F
2
P
0
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 19 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 2 F: 1 P: 2 S: 0 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
31
C187H334N92O36S2
4511.42
13.33
+21
14.59
-3.129
Free
Hyaluronic acid (HA) modified quaternary nanocomplexes (Q-complexes).
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Smmc-7722

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
Cy3-siRNA and Cy5.5-DSPE
Endocytosis efficiency of Q-complexes containing P1 and P2 was higher than that of Q-complexes containing P3.
Endocytosis
In vitro
CCSGGGGGGGGGGGGCCCCCCCCCCCCCTTC
Additional Detail Fields 1 fields
CCSGGGGGGGGGGGGCCCCCCCCCCCCCTTC