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Peptide record

TPDB63942

peptide 4 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB63942
peptide 4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Aliphatic moiety ILIL N-terminal: Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
Sequence
RRRRRRRRRRILIL-NH2
Physicochemical Analysis
C84H166N44O15
ANDCEQGHKMFPSTWYV
R
2032.53
13.35
10
0
4
+10
6.36
-2.029
111.43
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C84H166N44O15
2032.53
13.35
+10
6.36
-2.029
Amidation
Aliphatic moiety ILIL
L
Linear
Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hek293T

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein congugate I (NLS-mCherry-R10),Protein congugate II(NLS-mCherry-SS-R10) ,Protein congugate III (NLS-mCherry-SS-cR10) and protein conjugate IV (NLS-mCherry-R10-ILFF)
Cytosol And Nucleolar
Cotreatment of HeLa cells with I (5 μM) and CPP-additives 4 and 5 (5 μM) resulted in nucleolar signals, but less than 2.
Endocytosis
In vitro
CCCGGGGCCCSCC
Additional Detail Fields 1 fields
CCCGGGGCCCSCC