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Peptide record

TPDB63941

peptide 2 Cell-penetrating Peptides modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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Sequence-matched coordinates; source-recorded chemical modifications are not verified in this model.

TPDB63941
peptide 2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 14-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Hydrophobic moiety ILFF N-terminal: Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
Sequence
RRRRRRRRRRILFF-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
14 main sequence record
Amidation Activity
Hydrophobic moiety ILFF Activity
L Activity
Linear Activity
Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb) Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa , Hek293T, Skbr3, Sjsa1, MCF7 And Mdamb468, And Sw480

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein congugate I (NLS-mCherry-R10),Protein congugate II(NLS-mCherry-SS-R10) ,Protein congugate III (NLS-mCherry-SS-cR10)
Cytosol And Nucleolar
Coadministration of I (5 μM) with CPP-additives 1 or 2 (5 μM) in HeLa cells for one h resulted in nucleolar signals with more in 2. While no signals with protein conjugate I(NLS-mCherry-R10) alone
Direct transduction and endocytosis
In vitro
CCCCCSCCCC
Additional Detail Fields 1 fields
CCCCCSCCCC