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Peptide record

TPDB63938

peptide 3 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63938
peptide 3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Hydrophobic moiety FWF N-terminal: Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
Sequence
RRRRRRRRRRFWF-NH2
Physicochemical Analysis
C89H150N44O14
ANDCEQGHILKMPSTYV
R
2060.46
13.35
10
0
3
+10
3.99
-3.100
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
266.93
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C89H150N44O14
2060.46
13.35
+10
3.99
-3.100
Amidation
Hydrophobic moiety FWF
L
Linear
Conjugated with 5-Thio-2-Nitrobenzoic Acid-Disulfide (Tnb)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hek293T

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein congugate I (NLS-mCherry-R10),Protein congugate II(NLS-mCherry-SS-R10) ,Protein congugate III (NLS-mCherry-SS-cR10) and protein conjugate IV (NLS-mCherry-R10-ILFF)
Cytosol And Nucleolar
Endocytosis
In vitro
CCCCGGGSCSSCCC
Additional Detail Fields 1 fields
CCCCGGGSCSSCCC