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Peptide record

TPDB63926

RV24 Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB63926
RV24
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RRRRRRRRRGPGVTWTPQAWFQWV
Physicochemical Analysis
C141H222N56O29
NDCEHILKMSY
R
3165.67
13.30
9
0
7
+9
2.94
-1.775
28.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
521.22
4
Residue Composition
number
1
A
9
R
0
N
0
D
0
C
0
E
2
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
2
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 2 W: 3 Y: 0 V: 2
Chemical Descriptors
24
C141H222N56O29
3165.67
13.30
+9
2.94
-1.775
L
Amphipathic
Linear
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

T98G, HepG2 and HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Protein (?-galactosidase and eGFP)
RV24 peptide provides up to 5-fold increase in quantity delivered into 3 different cancer cell lines using b-galactosidase as a cargo protein
In vitro
CCCCCCCCCSSSCCCCCTTTSSCC
Additional Detail Fields 1 fields
CCCCCCCCCSSSCCCCCTTTSSCC