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Peptide record

TPDB63920

R9MPG Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB63920
R9MPG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
RRRRRRRRRGALFLAFLAAALSLMGC
Physicochemical Analysis
C132H233N53O28S2
NDEQHIKPTWYV
R
3074.76
12.94
9
0
13
+9
1.06
-0.158
94.23
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
5
A
9
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
5
L
0
K
1
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 5 K: 0 M: 1 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C132H233N53O28S2
3074.76
12.94
+9
1.06
-0.158
Addition of Cysteine
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)/N=C/C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors
Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Chimeric
Indocyanine green (ICG)-labeled Lactosomes (A3B-type)
In vitro and in vivo
CCCGGGSSCCCCCHHHHHHHHHTTTC
Additional Detail Fields 1 fields
CCCGGGSSCCCCCHHHHHHHHHTTTC