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Peptide record

TPDB63917

R9 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63917
R9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Mal-PEG3400-b-PHEP3800 via covalent thiol-maleimide linkage
Sequence
RRRRRRRRRC
Physicochemical Analysis
C57H115N37O11S1
ANDEQGHILKMFPSTWYV
R
1526.84
12.94
9
0
0
+9
7.05
-3.800
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C57H115N37O11S1
1526.84
12.94
+9
7.05
-3.800
Addition of Cysteine
Mal-PEG3400-b-PHEP3800 via covalent thiol-maleimide linkage
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 Cells

Assay & Model

Female BALB/c mice (6~8 weeks)
Female BALB/c mice (6~8 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Sensitive diblock copolymer PPC-DA and the insensitive PPC-SA conjugated DOX-nanoparticles
DA@R9-NPDOX at pH 6.5 were much stronger fluorescence signals of DOX than that at pH 7.4. In contrast, the enhanced fluorescence signals of DOX at pH 6.5 was not found for the SA@R9-NPDOX group.
In vitro and in vivo
CCCCCGGGTC
Additional Detail Fields 1 fields
CCCCCGGGTC