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Peptide record

TPDB63912

dendritic CPP Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB63912
dendritic CPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRRRRRKLLKLLKGSC
Physicochemical Analysis
C98H191N45O20S1
ANDEQHIMFPTWYV
R
2351.94
12.88
11
0
4
+11
7.11
-1.733
86.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
4
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C98H191N45O20S1
2351.94
12.88
+11
7.11
-1.733
Free
L
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nrf2 Activity Reporter K562 Cell Line And MCF7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Mel-permeabilized DL633- and A647-AnOs
Cytoplasm
DL633-ctrl/melAnOs with CPP greatly enhanced uptake into reporter cells.(MFI of ~threefold (from ~160 to ~500) for DL633-melAnOs with CPP over those lacking CPP)
In vitro
CCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCC