TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63906

Peptide_Name

R8-Lys

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0 MLCPP 2.0 Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 9-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.

Modification

C-terminal: Conjugated with CHOlesterol Chemical: Liposome N-terminal: Folate Ligand (Fa)

Sequence

RRRRRRRRK

FASTA

>TPDB63906|Cell-penetrating Peptides|length=9
RRRRRRRRK

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

9 reviewed residue count

C_terminal_Modification

Conjugated with CHOlesterol Activity

Chemical_Modification

Liposome Activity

Chirality

L Activity

Ionic_State

Cationic Activity

Linearity

Linear Activity

N_terminal_Modification

Folate Ligand (Fa) Activity

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line MDA-MB-231/Dox Cells

Assay & Model

In Vitro Model MDA-MB-231/DOX cells bearing Female nude mice

In Vivo Model MDA-MB-231/DOX cells bearing Female nude mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Synthetic

Cargo Type Doxorubicin and astragaloside IV co-modified

Subcellular Localization Around the Nucleus

Uptake Efficiency DOX uptake of FA-R8-LPs-treated tumor cells was much higher than that of other groups

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCSSSTTCCCTTTTC

DSSP_Secondary_Structure

CCCSSSTTCCCTTTTC