TPDB63902

SP2-332/336 (iSP2) (Octaarginine , R8) Cell-penetrating Peptides modified_plain modified

15 amino acids

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63902

Peptide_Name

SP2-332/336 (iSP2) (Octaarginine , R8)

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 15-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

N-terminal: Conjugated with FITC

Sequence

RRRRRRRRGGWPVIL

FASTA

>TPDB63902|Cell-penetrating Peptides|length=15
RRRRRRRRGGWPVIL

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

15 reviewed residue count

C_terminal_Modification

Free Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Conjugated with FITC Activity

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Jurkat Cells And El-4 Cells

Assay & Model

In Vitro Model C57BL/6 mice

In Vivo Model C57BL/6 mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Uptake Efficiency iSP2 peptide, which harbors the R8 sequence, was significantly incorporated into Jurkat and Raji cells.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCCCCSCCTTCCCCCCCC

DSSP_Secondary_Structure

CCCCCCCCCSCCTTCCCCCCCC