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Peptide record

TPDB63902

SP2-332/336 (iSP2) (Octaarginine , R8) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63902
SP2-332/336 (iSP2) (Octaarginine , R8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RRRRRRRRGGWPVIL
Physicochemical Analysis
C85H152N40O16
ANDCEQHKMFSTY
R
1990.40
13.25
8
0
4
+8
4.30
-1.787
71.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
276.33
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
15
C85H152N40O16
1990.40
13.25
+8
4.30
-1.787
Free
L
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cells And El-4 Cells

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
iSP2 peptide, which harbors the R8 sequence, was significantly incorporated into Jurkat and Raji cells.
In vitro and in vivo
CCCCCCCCCSCCTTCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCSCCTTCCCCCCCC