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Peptide record

TPDB63896

CPP-AIP Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB63896
CPP-AIP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Tetramethylrhodamine (TMR)
Sequence
RRRRRRRRGGVWNATFHIWHD
Physicochemical Analysis
C121H190N52O26
CEQLKMPSY
R
2789.17
12.88
10
1
6
+7
4.97
-1.876
37.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
394.38
2
Residue Composition
number
1
A
8
R
1
N
1
D
0
C
0
E
0
Q
2
G
2
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 8 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
21
C121H190N52O26
2789.17
12.88
+7
4.97
-1.876
Free
L
Linear
Conjugated with Tetramethylrhodamine (TMR)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
TMR dye
Cytoplasm
In vitro
CTTTTTTSCCCCCSSCCCC
Additional Detail Fields 1 fields
CTTTTTTSCCCCCSSCCCC