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Peptide record

TPDB63895

SP2-344/348 (iCont) (Octaarginine , R8) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63895
SP2-344/348 (iCont) (Octaarginine , R8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRRRRRGGPPAKL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H146N40O16
NDCEQHIMFSTWYV
R
1888.26
13.25
9
0
2
+9
7.75
-2.553
32.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
8
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15 reviewed residue count
C77H146N40O16 sequence-only estimate (linear, free termini)
1888.26 sequence-only estimate (linear, free termini)
13.25 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
7.75 sequence-only estimate (linear, free termini)
-2.553 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cells And El-4 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
In vitro
CCCCCCCCSSSCSCC
Additional Detail Fields 1 fields
CCCCCCCCSSSCSCC