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Peptide record

TPDB63890

R8-GC Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63890
R8-GC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
Sequence
RRRRRRRRGC
Physicochemical Analysis
C53H106N34O11S1
ANDEQHILKMFPSTWYV
R
1427.71
12.88
8
0
0
+8
6.25
-3.390
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C53H106N34O11S1
1427.71
12.88
+8
6.25
-3.390
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells Or A431 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Alexa488 or EGFP Dextran or Transferrin
Cytoplasm
Dextran and also EGFP-R8 uptake is signifcantly increased in A431 treated with Cyt D and contrasts to that observed for R8-Alexa488 (inhibition) and transferrin (no change). In HeLa cells, reduction in uptake of R8 Alexa488 and dextran and EGFP-R8 uptake by Cyt D treatment
In vitro
CCCSCTTSCC
Additional Detail Fields 1 fields
CCCSCTTSCC