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Peptide record

TPDB63884

R8 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63884
R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Sequence
RRRRRRRRC
Physicochemical Analysis
C51H103N33O10S1
ANDEQGHILKMFPSTWYV
R
1370.65
12.88
8
0
0
+8
6.24
-3.722
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C51H103N33O10S1
1370.65
12.88
+8
6.24
-3.722
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

LNCaP, SK-OV-3, and MCF-7 as Hpn-expressing cells, DU-145, PC-3, and HaCaT as Hpn-non-expressing cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore (FITC)
Cytoplasm
Higher than RIPL R8
Endocytic pathway
In vitro
CCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) polymers
Cytosol , Endoplasmic Reticulum and Mitochondria
R8PECL can increase the uptake by more than 12-fold.
Lipid-raft dependent endocytosis and macropinocytosis.
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC