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Peptide record

TPDB63883

R6-Pen(W-L) Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB63883
R6-Pen(W-L)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Linker Di-Glycine
Sequence
RRRRRRRQIKILFQNRRMKWKKGGC
Physicochemical Analysis
C142H252N60O29S2
ADEHPSTYV
R
3328.07
12.95
13
0
6
+13
8.22
-1.932
46.80
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
165.26
4
Residue Composition
number
0
A
9
R
1
N
0
D
1
C
0
E
2
Q
2
G
0
H
2
I
1
L
4
K
1
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 2 H: 0 I: 2 L: 1 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C142H252N60O29S2
3328.07
12.95
+13
8.22
-1.932
Free
Linker Di-Glycine
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HT-29-luc cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
PNA
Endocytosis
In vitro
CCSCGGGGSTTSCCCCCCCCSSSCC
Additional Detail Fields 1 fields
CCSCGGGGSTTSCCCCCCCCSSSCC