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Peptide record

TPDB63879

P7-4 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB63879
P7-4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RRRRRRRGGIYLATALAKWALKQGF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C134H226N50O29
NDCEHMPSV
R
3001.59
12.80
9
0
11
+9
3.55
-0.840
78.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
2.33
3
Residue Composition
number
4
A
7
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
1
I
3
L
2
K
0
M
1
F
0
P
0
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 3 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
25 reviewed residue count
C134H226N50O29 sequence-only estimate (linear, free termini)
3001.59 sequence-only estimate (linear, free termini)
12.80 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
3.55 sequence-only estimate (linear, free termini)
-0.840 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat and CHO

Assay & Model

Male white rats
Male white rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore [DiSC3(5)] and peptide P7-27
Mitochondria
In vitro and in vivo
CCCCCTTTTCCCHHHHHHHHHHHHC
Additional Detail Fields 1 fields
CCCCCTTTTCCCHHHHHHHHHHHHC