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Peptide record

TPDB63876

Arg7CLPFFD Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63876
Arg7CLPFFD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRRRRCLPFFD
Physicochemical Analysis
C78H132N34O16S1
ANEQGHIKMSTWYV
R
1834.18
12.53
7
1
3
+6
4.29
-1.900
30.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
7
R
0
N
1
D
1
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C78H132N34O16S1
1834.18
12.53
+6
4.29
-1.900
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Gold nanorods (GNR)
Multivesicular
Internalized 65% more nanoparticles (31 ± 7) than GNR-CLPFFD (11 ± 3) and 45% more than GNR-CArg7 (17 ± 2)
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC