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Peptide record

TPDB63874

[R6K]W6 Cell-penetrating Peptides modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63874
[R6K]W6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 13-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Sequence
RRRRRRKWWWWWW
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
13 reviewed residue count
Free Activity
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) Activity
L Activity
Amphipathic Activity
Cyclic Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, MDA-MB-468 , Llcpk And Au565 Wt Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Amphipathic
Synthetic
5-carboxyfluorescein (FAM)-labeled siRNA
Cytoplasm
The addition of DOPE had a more significant effect on improving the internalization level with [R6K]W6 compared to [R5K]W5 at N/P ratios of 40 and 80 (mean fluorescence of 1359 compared to 671 for N/P ratio of 40, respectively ) in MDA-MB-231 cells,
In vitro
CCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCC