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Peptide record

TPDB63874

[R6K]W6 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63874
[R6K]W6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Sequence
RRRRRRKWWWWWW
Physicochemical Analysis
C108H146N38O14
ANDCEQGHILMFPSTYV
RW
2200.59
13.10
7
0
6
+7
-5.25
-2.792
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
33000
1499.60
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
13
C108H146N38O14
2200.59
13.10
+7
-5.25
-2.792
Free
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
L
Amphipathic
Cyclic
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, MDA-MB-468 , Llcpk And Au565 Wt Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Amphipathic
Synthetic
5-carboxyfluorescein (FAM)-labeled siRNA
Cytoplasm
The addition of DOPE had a more significant effect on improving the internalization level with [R6K]W6 compared to [R5K]W5 at N/P ratios of 40 and 80 (mean fluorescence of 1359 compared to 671 for N/P ratio of 40, respectively ) in MDA-MB-231 cells,
In vitro
CCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCC