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Peptide record

TPDB63868

R6ST Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB63868
R6ST
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Rhodamine-B-labeling
Sequence
RRRRRRAVPIVRERGPQRVA
Physicochemical Analysis
C103H190N48O24
NDCHLKMFSTWY
R
2484.95
12.94
9
1
6
+8
10.36
-1.520
73.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
9
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 9 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
20
C103H190N48O24
2484.95
12.94
+8
10.36
-1.520
Free
Rhodamine-B-labeling
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Panc-1 Cells

Assay & Model

PANC-1 pancreatic cancer xenograft Female BALB/c nude mice (5–6 weeks)
PANC-1 pancreatic cancer xenograft Female BALB/c nude mice (5–6 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Artesunate (ART) loaded NPs labelled with Coumarin 6
Cytoplasm
mean fluorescence intensity of Cou in cells treated with Rho-R6ST-Cou-NPs was prominently higher than those treated with Cou-NPs and free Cou.
In vitro and in vivo
CCCCCCSCCCSSCSSSTTCC
Additional Detail Fields 1 fields
CCCCCCSCCCSSCSSSTTCC