TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63868

Peptide_Name

R6ST

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 20-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

Chemical: Rhodamine-B-labeling

Sequence

RRRRRRAVPIVRERGPQRVA

FASTA

>TPDB63868|Cell-penetrating Peptides|length=20
RRRRRRAVPIVRERGPQRVA

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

20 reviewed residue count

C_terminal_Modification

Free Activity

Chemical_Modification

Rhodamine-B-labeling Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Free Activity

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Panc-1 Cells

Assay & Model

In Vitro Model PANC-1 pancreatic cancer xenograft Female BALB/c nude mice (5–6 weeks)

In Vivo Model PANC-1 pancreatic cancer xenograft Female BALB/c nude mice (5–6 weeks)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Chimeric

Cargo Type Artesunate (ART) loaded NPs labelled with Coumarin 6

Subcellular Localization Cytoplasm

Uptake Efficiency

mean fluorescence intensity of Cou in cells treated with Rho-R6ST-Cou-NPs was prominently higher than those treated with Cou-NPs and free Cou.

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCCCCSCCCSSCSSSTTCC

DSSP_Secondary_Structure

CCCCCCSCCCSSCSSSTTCC