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Peptide record

TPDB63867

R6AANCK peptide Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB63867
R6AANCK peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
RRRRRRAANCK
Physicochemical Analysis
C55H107N31O13S1
DEQGHILMFPSTWYV
R
1442.71
12.70
7
0
2
+7
5.69
-2.573
18.18
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
6
R
1
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C55H107N31O13S1
1442.71
12.70
+7
5.69
-2.573
Free
Nanoparticles
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Du145 Cells

Assay & Model

Female Rag2−/− mice (20–25 g)
Female Rag2−/− mice (20–25 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Alexa Fluor 488-conjugated
Cytosol
R6 exhibited the lowest CP50 at 0.8 μM at 60min incubation (corresponding to the highest cellular uptake).
In vitro and in vivo
CCSSCC
Additional Detail Fields 1 fields
CCSSCC