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Peptide record

TPDB63857

Rq Cell-penetrating Peptides modified_plain modified
9 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63857
Rq
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 9-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
RRRRQWWQW
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
9 reviewed residue count
Conjugated with FITC Activity
L Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Assay & Model

Female BALB/c mice (4–6 weeks old and weighing 18–22 g).
Female BALB/c mice (4–6 weeks old and weighing 18–22 g).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Paclitaxel (PTX)
Cytoplasm
Obvious green fluorescence was observed in the presence of both 10 and 100 μM Rq-FITC, while no fluorescence was observed in the untreated cells and cells treated with FITC alone. The intracellular PTX concentration of the Rq/PTX group was nearly seven-fold greater than that of the free PTX group after 30 minutes.
Direct translocation
In vitro and in vivo