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Peptide record

TPDB63857

Rq Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB63857
Rq
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
RRRRQWWQW
Physicochemical Analysis
C67H96N26O12
ANDCEGHILKMFPSTYV
R
1457.67
12.88
4
0
3
+4
-1.15
-3.078
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1131.95
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9
C67H96N26O12
1457.67
12.88
+4
-1.15
-3.078
Conjugated with FITC
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Assay & Model

Female BALB/c mice (4–6 weeks old and weighing 18–22 g).
Female BALB/c mice (4–6 weeks old and weighing 18–22 g).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Paclitaxel (PTX)
Cytoplasm
Obvious green fluorescence was observed in the presence of both 10 and 100 μM Rq-FITC, while no fluorescence was observed in the untreated cells and cells treated with FITC alone. The intracellular PTX concentration of the Rq/PTX group was nearly seven-fold greater than that of the free PTX group after 30 minutes.
Direct translocation
In vitro and in vivo