TPDB

3D PDB MODEL

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TPDB ID TPDB63854

Peptide_Name

FHV FHV Coat

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.

Sequence

RRRRNRTRRNRRRVR

FASTA

>TPDB63854|Cell-penetrating Peptides|length=15
RRRRNRTRRNRRRVR

Formula C83H162N50O19

Absent Amino Acids ADCEQGHILKMFPSWY

Common Amino Acids R

Mass 2164.52

PI 13.40

Basic Residues 11

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +11

Boman Index 9.96

Hydrophobicity -3.533

Aliphatic Index 19.33

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

11

R

2

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 11 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

15

Formula

C83H162N50O19

Mass

2164.52

PI

13.40

Net Charge

+11

Boman Index

9.96

Hydrophobicity

-3.533

C_terminal_Modification

Free

Chirality

L

Ionic_State

Cationic

Linearity

Linear

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)/C/1=N/[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC2=CN=C(C)/C/2=C\C)C(=O)N[C@@H](CC2=CN=C(C)/C/2=C\C)C(=O)N[C@@H](CCCN=C)C(=O)OO1

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line HEK293 And HeLa Cells

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Cargo Type FITC-labelled

Subcellular Localization Cytosol and Nucleus

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSCCSSCCCSSSCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Jurkat T Clone E6-1, H9 T Cells, PBMCs And MAGI-CCR5

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type anti-p24 mAb

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCSCCSSCCCSSSCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L Cationic

Source of Peptide Protein derived

DSSP Secondary Structure CCGGGSSCC

Evidence 4 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice

In Vivo Model Normal BL6 mice, dystrophin-null mdx4cv mice and ∆R4 transgenic mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Non-natural residues Linear L

Source of Peptide Protein derived

Cargo Type Palmitoylated (Pal) R16/17-GFP protein

In Vitro or In Vivo In vivo

DSSP_Secondary_Structure

CCSCCSSCCCSSSCC CCGGGSSCC