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Peptide record

TPDB63849

R4-DCpep-2(V2W/K4R/ox)-NH2 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63849
R4-DCpep-2(V2W/K4R/ox)-NH2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Addition of Methylated Cysteine Methylated
Sequence
RRRRCWARYHGYPWCRRRR-NH2
Physicochemical Analysis
C116H180N50O22S2
NDEQILKMFSTV
R
2691.15
12.31
10
0
5
+9
2.48
-2.279
5.26
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
14105
524.13
4
Residue Composition
number
1
A
9
R
0
N
0
D
2
C
0
E
0
Q
1
G
1
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
19
C116H180N50O22S2
2691.15
12.31
+9
2.48
-2.279
Amidation
L
Cyclic
Addition of Methylated Cysteine Methylated
N[C@@H](CS)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Luciferin
Cytosol
All luciferin-conjugated peptides showed a luminescence signal in a peptide-concentration dependent manner except for luciferin-DCpep-3-OH
In vitro
CCTTSSSCSCTTC
Additional Detail Fields 1 fields
CCTTSSSCSCTTC