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Peptide record

TPDB63848

R4 Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB63848
R4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C27H55N17O6S1
ANDEQGHILKMFPSTWYV
R
745.90
12.40
4
0
0
+4
11.68
-3.100
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5 reviewed residue count
C27H55N17O6S1 sequence-only estimate (linear, free termini)
745.90 sequence-only estimate (linear, free termini)
12.40 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
11.68 sequence-only estimate (linear, free termini)
-3.100 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) polymers
Lysosomes
R4PECL can increase the uptake by 5-fold.
Lipid-raft mediated endocytosis
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCC