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Peptide record

TPDB63848

R4 Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB63848
R4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRRC
Physicochemical Analysis
C27H55N17O6S1
ANDEQGHILKMFPSTWYV
R
745.90
12.40
4
0
0
+4
3.00
-3.100
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H55N17O6S1
745.90
12.40
+4
3.00
-3.100
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) polymers
Lysosomes
R4PECL can increase the uptake by 5-fold.
Lipid-raft mediated endocytosis
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCC