Back to search

Peptide record

TPDB63832

Iduna Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63832
Iduna
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 7-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RRRKIKR
Physicochemical Analysis
C42H85N21O8
ANDCEQGHLMFPSTWYV
R
1012.27
12.88
6
0
1
+6
4.91
-3.043
55.71
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H85N21O8
1012.27
12.88
+6
4.91
-3.043
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat T Cells, And HeLa Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
EGFP protein
Cytoplasm and nucleus
EGFP uptake by cells treated with 10 µM Iduna-EGFP was two-times higher than that of PBS- or EGFP-treated control groups
Lipid-raft mediated endocytosis
In vitro
CCSSCCCCCCCCCCCSSCCCC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCCSSCCCC