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Peptide record

TPDB63828

Oleyl-R3-(HR)4 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB63828
Oleyl-R3-(HR)4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Acylation With Oleic Acid
Sequence
RRRHRHRHRHR
Physicochemical Analysis
C66H114N40O12
ANDCEQGILKMFPSTWYV
R
1659.89
13.18
11
0
0
+7
9.51
-4.027
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C66H114N40O12
1659.89
13.18
+7
9.51
-4.027
Free
L
Cationic
Linear
Acylation With Oleic Acid
N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231, MCF-7 And MCF-10A Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Alexa Fluor 488 labeled siRNA
~80-fold increased cellular uptake than free siRNA
In vitro
CCCCCCCTTSCC
Additional Detail Fields 1 fields
CCCCCCCTTSCC