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Peptide record

TPDB63826

Stearyl-R3H5 Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB63826
Stearyl-R3H5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Stearylation
Sequence
RRRHHHHH
Physicochemical Analysis
C48H73N27O9
ANDCEQGILKMFPSTWYV
H
1172.28
12.70
8
0
0
+3
7.23
-3.687
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
5
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 5 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H73N27O9
1172.28
12.70
+3
7.23
-3.687
Free
L
Cationic
Linear
Stearylation
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Scl-1 Cells

Assay & Model

SCL-1 tumor bearing Nude mice (BALB/c-nu, female, 4–5 weeks old)
SCL-1 tumor bearing Nude mice (BALB/c-nu, female, 4–5 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Lycorine-oleic acid ionic complex (LR-OA)
CPP-modifed C6-loaded transfersomes exhibited stronger intracellular green fuorescence intensity than unmodifed C6-loaded transfersomes,
Endocytosis
In vitro and in vivo
CCCCCCTTCC
Additional Detail Fields 1 fields
CCCCCCTTCC