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Peptide record

TPDB63802

M593 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB63802
M593
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
RRKLSQQKEKK-NH2
Physicochemical Analysis
C60H113N23O17
ANDCGHIMFPTWYV
K
1428.70
11.63
6
1
1
+5
8.33
-2.918
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
2
Q
0
G
0
H
0
I
1
L
4
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C60H113N23O17
1428.70
11.63
+5
8.33
-2.918
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human SH-SY5Y, N2A and Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Lower than penetratin
In vitro
CCCCSTTTSCC
Additional Detail Fields 1 fields
CCCCSTTTSCC