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Peptide record

TPDB63800

H7K(R2)2 (CPP) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63800
H7K(R2)2 (CPP)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Dir-labelled SPIO Nanoparticle N-terminal: Acetylation
Sequence
Ac-RRKHHHHHHHRR-NH2
Physicochemical Analysis
C72H111N39O13
ANDCEQGILMFPSTWYV
H
1730.93
12.88
12
0
0
+6
10.95
-3.692
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
7
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 7 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C72H111N39O13
1730.93
12.88
+6
10.95
-3.692
Amidation
Dir-labelled SPIO Nanoparticle
L
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cell Line

Assay & Model

Female BALB/c nude mice (18–20 g)
Female BALB/c nude mice (18–20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Paclitaxel (PTX)
DiR fluorescence signal at the tumor site for the mice treated with DiR/SPIO-SSL-H7K(R2)2 was stronger than in those treated with DiR/SPIO-SSL at all observed time points.
In vitro and in vivo
CHHHHTTTC
Additional Detail Fields 1 fields
CHHHHTTTC