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Peptide record

TPDB63800

H7K(R2)2 (CPP) Cell-penetrating Peptides modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63800
H7K(R2)2 (CPP)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 12-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Dir-labelled SPIO Nanoparticle N-terminal: Acetylation
Sequence
Ac-RRKHHHHHHHRR-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
12 reviewed residue count
Amidation Activity
Dir-labelled SPIO Nanoparticle Activity
L Activity
Linear Activity
Acetylation Activity
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cell Line

Assay & Model

Female BALB/c nude mice (18–20 g)
Female BALB/c nude mice (18–20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Paclitaxel (PTX)
DiR fluorescence signal at the tumor site for the mice treated with DiR/SPIO-SSL-H7K(R2)2 was stronger than in those treated with DiR/SPIO-SSL at all observed time points.
In vitro and in vivo
CHHHHTTTC
Additional Detail Fields 1 fields
CHHHHTTTC