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Peptide record

TPDB63792

CPP Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB63792
CPP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Collagen N-terminal: Acylation
Sequence
RRGRRG-NH2
Physicochemical Analysis
C28H56N18O7
ANDCEQHILKMFPSTWYV
R
756.87
12.88
4
0
0
+4
3.26
-3.133
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C28H56N18O7
756.87
12.88
+4
3.26
-3.133
Amidation
Collagen
L
Linear
Acylation
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkats-E6 And A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-labeled via β alanine–glycine–glycine linker
Cytoplasm
At lower concentrations of FITC-COL-CPP, a much larger percentage of Jurkat cells (75% at 10 μM) than A549 cells (21% at 10 μM) are able to uptake the peptide carrier.
In vitro
CCSSSSSSGGGSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Jurkats-E6 And A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Paclitaxel (PTX)
Cytoplasm
In vitro
CCSCCC
Additional Detail Fields 1 fields
CCSSSSSSGGGSCC CCSCCC