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Peptide record

TPDB63778

HoxA-13 Blood-Brain Barrier Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63778
HoxA-13
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 16-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Cyanine5.5 (Cy5.5)
Sequence
RQVTIWFQNRRVKEKK
Physicochemical Analysis
C95H158N32O23
ADCGHLMPSY
RK
2116.50
12.14
6
1
5
+5
5.99
-1.569
60.62
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
259.86
4
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
1
E
2
Q
0
G
0
H
1
I
0
L
3
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 0 H: 0 I: 1 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 2
Chemical Descriptors
16
C95H158N32O23
2116.50
12.14
+5
5.99
-1.569
Free
L
Cationic
Linear
Conjugated with Cyanine5.5 (Cy5.5)
N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Human Astrocytes

Assay & Model

7-week-old female nude mice
7-week-old female nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cy5.5 dye and fluorescein isothiocyanate (FITC)-dextran
Highest fluorescence level inside the spheroids
In vitro and in vivo
CCSSCCCCSSCCCCSCCC
Additional Detail Fields 1 fields
CCSSCCCCSSCCCCSCCC