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Peptide record

TPDB63772

PenArg-Cys Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB63772
PenArg-Cys
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Cysteine modification
Sequence
RQIRIWFQNRRMRWRRC
Physicochemical Analysis
C107H173N43O21S2
ADEGHLKPSTYV
R
2461.95
12.80
7
0
6
+7
1.33
-1.624
45.88
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
446.80
4
Residue Composition
number
0
A
7
R
1
N
0
D
1
C
0
E
2
Q
0
G
0
H
2
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C107H173N43O21S2
2461.95
12.80
+7
1.33
-1.624
Cysteine modification
L
Linear
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEK293T cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (Plasmid DNA)
Cytoplasm
PenArg-Cys showed transfection efficiencies as high as 40% despite the low charge ratio
Endocytosis
In vitro
CCCCCCCCCCSCSSCCC
Additional Detail Fields 1 fields
CCCCCCCCCCSCSSCCC