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Peptide record

TPDB63771

Pen-iCAL36 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63771
Pen-iCAL36
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: TAMRA-labelled
Sequence
RQILIWFQNRRMKWKK
Physicochemical Analysis
C104H167N33O20S1
ADCEGHPSTYV
RK
2231.74
12.71
6
0
7
+6
0.74
-1.250
73.12
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
492.89
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
1
L
3
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 1 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C104H167N33O20S1
2231.74
12.71
+6
0.74
-1.250
Free
TAMRA-labelled
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 And Calu-3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
TAMRA dye and iCAL36 peptide
Cytoplasm
MPG-iCAL36 and Pen-iCAL36 seemed to be superior uptake than Tat-iCAL36 and its analogs in both cell lines.
More than one endocytosis pathways
In vitro
CCCSCCCTTCSSSTTC
Additional Detail Fields 1 fields
CCCSCCCTTCSSSTTC