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Peptide record

TPDB63768

9-W Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB63768
9-W
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FAM via Lysine residue
Sequence
RQIKIWFQWRRMKWKK
Physicochemical Analysis
C111H172N34O19S1
ANDCEGHLPSTYV
K
2318.86
12.72
7
0
7
+7
0.02
-1.569
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
711.56
2
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
16
C111H172N34O19S1
2318.86
12.72
+7
0.02
-1.569
Conjugated with FAM via Lysine residue
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcec And Nhc Cells

Assay & Model

Male mice (18 − 20 g)
Male mice (18 − 20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye
Cytoplasm
For the HCEC cells, all the hydrophobic derivatives except 29-W (p < 0.01) internalized significantly more than did the wild-type penetratin (p < 0.001). The increased folds of uptake ranged from 1.7 (29-W) to 7.7 (89-W).
In-vitro, in-vivo and ex vivo
CCSCCSCCSSCBTTBC
Additional Detail Fields 1 fields
CCSCCSCCSSCBTTBC