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Peptide record

TPDB63767

MAAPC01 (Pentobra) MAAPC05 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63767
MAAPC01 (Pentobra) MAAPC05
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RQIKIWFQNRRW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C81H123N27O16
ADCEGHLMPSTYV
R
1731.04
12.71
4
0
5
+4
4.21
-1.492
65.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
6.35
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C81H123N27O16 sequence-only estimate (linear, free termini)
1731.04 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
4.21 sequence-only estimate (linear, free termini)
-1.492 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Cationic Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli D31 And E. Coli Ml35 And Hrbcs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
aminoglycoside tobramycin at N terminal
MAAPC01 and MAAPC05 exhibited the highest permeation effect, which was compared to control (melittin).
In vitro
CCHHHHTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli D31 And E. Coli Ml35 And Hrbcs

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
aminoglycoside tobramycin at C terminal
MAAPC01 and MAAPC05 exhibited the highest permeation effect, which was compared to control (melittin).
In vitro
CCTTTGGGTTTC
Additional Detail Fields 1 fields
CCHHHHTTCC CCTTTGGGTTTC