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Peptide record

TPDB63764

pAntp–PKI Cell-penetrating Peptides standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB63764
pAntp–PKI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 33-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
RQIKIWFQNRRMKWKKTYADFIASGRTGRRNAI
Physicochemical Analysis
C184H295N61O44S1
CEHLPV
R
4097.81
12.42
10
1
13
+9
3.60
-1.070
56.36
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
304.80
8
Residue Composition
number
3
A
6
R
2
N
1
D
0
C
0
E
2
Q
2
G
0
H
4
I
0
L
4
K
1
M
2
F
0
P
1
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 2 D: 1 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 4 L: 0 K: 4 M: 1 F: 2 P: 0 S: 1 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
33
C184H295N61O44S1
4097.81
12.42
+9
3.60
-1.070
Free
L
Linear
Conjugation with rhodamine B
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO K1, HeLa, A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (rhodamine)
Less than Polyarginine-PKI and transportan-PKI but
Lipid raft-dependent but clathrin-independent endocytic process
In vitro
CCSSSCCCCSCCCCSSSCCCCCCCCCSSCCCCC
Additional Detail Fields 1 fields
CCSSSCCCCSCCCCSSSCCCCCCCCCSSCCCCC