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Peptide record

TPDB63762

AntpMUC1Kb Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB63762
AntpMUC1Kb
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKSAPDTRPAP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C142H228N46O33S1
CEGHLYV
RK
3139.72
12.42
8
1
8
+7
3.63
-1.536
39.20
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
3.50
5
Residue Composition
number
2
A
4
R
1
N
1
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
3
P
1
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 1 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 3 S: 1 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
25 reviewed residue count
C142H228N46O33S1 sequence-only estimate (linear, free termini)
3139.72 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
3.63 sequence-only estimate (linear, free termini)
-1.536 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Cells

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chimeric
MUC1-H-2Kb Epitope
Cytoplasm
AntpMUC1Kb show substantial peptide internalisation of 48%
Macropinocytosis or Phagocytosis
In vitro and in vivo