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Peptide record

TPDB63760

Pen-GFP-Pen Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB63760
Pen-GFP-Pen
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKRQIKIWFQNRRMKWK
Physicochemical Analysis
C202H322N66O38S2
ADCEGHLPSTYV
K
4347.32
13.11
13
0
12
+13
3.59
-1.661
50.32
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
506.06
6
Residue Composition
number
0
A
6
R
2
N
0
D
0
C
0
E
4
Q
0
G
0
H
4
I
0
L
7
K
2
M
2
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 2 D: 0 C: 0 E: 0 Q: 4 G: 0 H: 0 I: 4 L: 0 K: 7 M: 2 F: 2 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
31
C202H322N66O38S2
4347.32
13.11
+13
3.59
-1.661
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC-3 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Protein (eGFP)
Unable to penetrate PC-3 cells at 100 nM concentartion
Endocytic pathway
In vitro
CCCCCCCCCCCCSCTTTCCCCCGGGCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCSCTTTCCCCCGGGCCCCCC