Back to search

Peptide record

TPDB63759

FITC-P16-NLS Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63759
FITC-P16-NLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: NLS Attached N-terminal: Conjugated with FITC
Sequence
RQIKIWFQNRRMKWKKPKKKRKV
Physicochemical Analysis
C144H244N48O27S1
ADCEGHLSTY
K
3111.89
12.90
12
0
7
+12
7.58
-1.965
46.52
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
353.48
3
Residue Composition
number
0
A
4
R
1
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
8
K
1
M
1
F
1
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 8 M: 1 F: 1 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
23
C144H244N48O27S1
3111.89
12.90
+12
7.58
-1.965
NLS Attached
L
Linear
Conjugated with FITC
N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
FITC dye
Cytosol and Nucleus
FITC-P16-NLS was diffuse throughout the cytosol and nucleus, indicating that the peptide successfully reached the cytosol and was efficiently trafficked to the nucleus
In vitro
CCCCCCSSCCSSSCCCCC
Additional Detail Fields 1 fields
CCCCCCSSCCSSSCCCCC