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Peptide record

TPDB63758

Dpep Cell-penetrating Peptides standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB63758
Dpep
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 46-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKLVELSAENEKLHQRVEQLTRDLAGLRQFFK
Physicochemical Analysis
C262H425N81O66S1
CPY
RLK
5797.82
11.46
13
5
18
+7
13.59
-0.983
84.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
189.73
9
Residue Composition
number
2
A
6
R
2
N
1
D
0
C
4
E
5
Q
1
G
1
H
2
I
6
L
6
K
1
M
3
F
0
P
1
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 6 N: 2 D: 1 C: 0 E: 4 Q: 5 G: 1 H: 1 I: 2 L: 6 K: 6 M: 1 F: 3 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
46
C262H425N81O66S1
5797.82
11.46
+7
13.59
-0.983
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

T98G, Ln229, U251, MDA-MB-231, MCF7, MDA-MB-468, A549, Hct116, A375, Mewo, Hek293T And B16-F10 Cells

Assay & Model

A375 HCT116 or B16-F10 cells bearing 6–8 week-old female NCR nude mice
A375 HCT116 or B16-F10 cells bearing 6–8 week-old female NCR nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
In vitro and in vivo
CCCCCCCTTCCHHHHCSSCCSSSSSCSSCCCCCCCSHHHHHHHCC
Additional Detail Fields 1 fields
CCCCCCCTTCCHHHHCSSCCSSSSSCSSCCCCCCCSHHHHHHHCC