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Peptide record

TPDB63756

RT39 Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB63756
RT39
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKLQYFARGLQVYIRQLRLALQGGKT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C232H376N72O51S1
DCEHPS
RQ
5022.05
12.42
11
0
18
+11
2.43
-0.737
90.25
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
2.78
10
Residue Composition
number
2
A
6
R
1
N
0
D
0
C
0
E
6
Q
3
G
0
H
3
I
5
L
5
K
1
M
2
F
0
P
0
S
1
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 6 G: 3 H: 0 I: 3 L: 5 K: 5 M: 1 F: 2 P: 0 S: 0 T: 1 W: 2 Y: 2 V: 1
Chemical Descriptors
40 reviewed residue count
C232H376N72O51S1 sequence-only estimate (linear, free termini)
5022.05 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+11 sequence-only estimate (linear, free termini)
2.43 sequence-only estimate (linear, free termini)
-0.737 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

P. Berghei (Pb), P. Yoelii (Py), And P. Falciparum (Pf) Sporozoites

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
To-Pro 3 and FITC dye
In vitro
CCCCCCCTTCCCCCCCCCCCCCCCCCCSSSCCGGGCC
Additional Detail Fields 1 fields
CCCCCCCTTCCCCCCCCCCCCCCCCCCSSSCCGGGCC