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Peptide record

TPDB63749

CPP-SAP Cell-penetrating Peptides standard
59 amino acids
Basic Information
3D PDB MODEL
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TPDB63749
CPP-SAP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 59-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugation with 6 His-Tag
Sequence
RQIKIWFQNRRMKWKKGGVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALHHHHHH
Physicochemical Analysis
C324H539N107O78S2
CPTY
K
7245.63
11.35
24
6
20
+13
25.52
-1.234
81.02
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
151.82
6
Residue Composition
number
3
A
6
R
1
N
1
D
0
C
5
E
3
Q
3
G
6
H
2
I
8
L
12
K
2
M
1
F
0
P
2
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 1 C: 0 E: 5 Q: 3 G: 3 H: 6 I: 2 L: 8 K: 12 M: 2 F: 1 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
59
C324H539N107O78S2
7245.63
11.35
+13
25.52
-1.234
Conjugation with 6 His-Tag
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Primary Fibroblasts, T47D, MDA-MB231, Crl2327, Hff1, MCF10A, Umuc3, Hct116, Du145, And Ht1082

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
SAP (SAF-A/B acinus, and PIAS) domains
Nucleus
CPP-SAP had marked effects on proliferation, growth and the epigenetic landscape by driving chromatin compaction and global loss of active histone marks in cancer cells benign (MCF10A) or treatment-resistant cancer cells (HT1080) were un- or minimally affected.
In vitro
CCSSEECSSCCBTTBCEEESCCCSSCCCSSSSCC
Additional Detail Fields 1 fields
CCSSEECSSCCBTTBCEEESCCCSSCCCSSSSCC