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Peptide record

TPDB63747

CPP-RGG Cell-penetrating Peptides standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB63747
CPP-RGG
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 50-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugation with 6 His-Tag
Sequence
RQIKIWFQNRRMKWKKGGMRGGNFRGGAPGNRGGYNRRGNMPQRHHHHHH
Physicochemical Analysis
C258H399N103O60S3
DCELSTV
G
5999.84
12.95
19
0
11
+14
13.47
-1.830
17.60
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
208.17
9
Residue Composition
number
1
A
9
R
5
N
0
D
0
C
0
E
3
Q
10
G
6
H
2
I
0
L
4
K
3
M
2
F
2
P
0
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 5 D: 0 C: 0 E: 0 Q: 3 G: 10 H: 6 I: 2 L: 0 K: 4 M: 3 F: 2 P: 2 S: 0 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
50
C258H399N103O60S3
5999.84
12.95
+14
13.47
-1.830
Conjugation with 6 His-Tag
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Primary Fibroblasts, T47D, MDA-MB231, Crl2327, Hff1, MCF10A, Umuc3, Hct116, Du145, And Ht1083

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
RGG (arginine-glycine-glycine) domain
Nucleus
CPP-RGG markedly decreases proliferation, total cell number, and Ki67+ cells, while the effect of CPP-SAP was more modest in human primary fibroblasts. CPP-RGG had effects on proliferation, survival, and splicing/splicing machinery in all cell types
In vitro
CCCSCCTTCCSCSCCCCBCSCSTTTTSCSCCCCCCSSHHHHTTHHHHTTTBCC
Additional Detail Fields 1 fields
CCCSCCTTCCSCSCCCCBCSCSTTTTSCSCCCCCCSSHHHHTTHHHHTTTBCC