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Peptide record

TPDB63745

CPP-L491-L508 Cell-penetrating Peptides standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB63745
CPP-L491-L508
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 42-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
RQIKIWFQNRRMKWKKGGLHGRWFAGKMITAAYVPLHHHHHH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C241H361N79O48S2
DCES
H
5197.14
12.43
16
0
17
+10
2.02
-0.910
60.48
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
17990
3.46
5
Residue Composition
number
3
A
4
R
1
N
0
D
0
C
0
E
2
Q
4
G
7
H
3
I
2
L
5
K
2
M
2
F
1
P
0
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 4 H: 7 I: 3 L: 2 K: 5 M: 2 F: 2 P: 1 S: 0 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
42 reviewed residue count
C241H361N79O48S2 sequence-only estimate (linear, free termini)
5197.14 sequence-only estimate (linear, free termini)
12.43 sequence-only estimate (linear, free termini)
+10 sequence-only estimate (linear, free termini)
2.02 sequence-only estimate (linear, free termini)
-0.910 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bc Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chimeric
Nucleus
In vitro