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Peptide record

TPDB63741

CPP-Act Cell-penetrating Peptides modified_plain modified
40 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63741
CPP-Act
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 40-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugation with 6 His-Tag
Sequence
RQIKIWFQNRRMKWKKGGEDYKQRTQKKAEVEGKHHHHHH
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
40 reviewed residue count
Conjugation with 6 His-Tag Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Primary Fibroblasts, T47D, MDA-MB231, Crl2327, Hff1, MCF10A, Umuc3, Hct116, Du145, And Ht1081

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
SAFA-actin complex
Nucleus
CPP-Act did not affect cell proliferation of human primary fibroblasts.
In vitro
CCCCSCCSSCC
Additional Detail Fields 1 fields
CCCCSCCSSCC