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Peptide record

TPDB63741

CPP-Act Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB63741
CPP-Act
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugation with 6 His-Tag
Sequence
RQIKIWFQNRRMKWKKGGEDYKQRTQKKAEVEGKHHHHHH
Physicochemical Analysis
C226H351N79O56S1
CLPS
K
5102.83
10.98
18
4
9
+9
20.40
-2.130
29.25
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
244.77
7
Residue Composition
number
1
A
4
R
1
N
1
D
0
C
3
E
4
Q
3
G
6
H
2
I
0
L
8
K
1
M
1
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 1 C: 0 E: 3 Q: 4 G: 3 H: 6 I: 2 L: 0 K: 8 M: 1 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
40
C226H351N79O56S1
5102.83
10.98
+9
20.40
-2.130
Conjugation with 6 His-Tag
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Primary Fibroblasts, T47D, MDA-MB231, Crl2327, Hff1, MCF10A, Umuc3, Hct116, Du145, And Ht1081

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
SAFA-actin complex
Nucleus
CPP-Act did not affect cell proliferation of human primary fibroblasts.
In vitro
CCCCSCCSSCC
Additional Detail Fields 1 fields
CCCCSCCSSCC